Triple S Ventures Invested in 18 Companies: Co-Founder Avag Simonyan on What’s Next for Early-Stage Tech in 2025

Avag, Triple S Ventures has just surpassed 18 investments since its 2022 launch. What inspired you to co-found the firm, and how has its mission evolved to date?

Avag Simonyan: Thank you. Triple S was born in 2022 out of a shared vision between my co-founders, Artur Janibekyan and Hakob Hakobyan, and me: back visionary entrepreneurs building technologies that deliver positive global change. Nearly three years in, that mission is unchanged. What has evolved is the depth of the relationships we cultivate with founders—we now have a playbook for hands-on value creation that ranges from talent introductions to cross-border market entry.

To date Triple S has invested in 18 companies across multiple sectors and regions. Could you spotlight a few and the impact they’re making?

Avag Simonyan: Certainly. Our portfolio spans AI, biotech, health-tech, quantum computing, cloud, and sustainability, with footprints in the United States, Armenia, the UK, and the EU. Collectively these companies have raised more than $40 million. Standouts include BlueQubit, Sparxell, Waveye, Denovo Sciences, Docus, CloudChipr, Modicus Prime, SimCare AI—each pushing the frontier in its field.

One illustrative case is Denovo Sciences. Their AI-native platform is redefining drug discovery by generating novel chemical structures in data-scarce environments. Triple S didn’t just write a check; we also facilitated their strategic partnership with Alchemist Doha, which brought an additional $1 million to the table and opened MENA market doors.

Sparxell is another standout startup, engineering fully biodegradable pigments for the fashion and cosmetics industries and already collaborating with leaders such as L’Oréal, Chanel, LVMH, Nike, H&M, Hermès, Kering, Moncler, BMW, and more.

Triple S Ventures is also active in the Armenian startup ecosystem. How has that focus influenced the local entrepreneurial landscape?

Avag Simonyan: Armenia is one of the cornerstones of our strategy. By investing in local startups and fostering a collaborative environment, we aim to turn the country into a hub of technological innovation. Beyond capital, we provide founders with infrastructure—sponsoring events such as the Sevan Startup Summit, where young entrepreneurs can connect with investors, mentors, and partners. We also leverage our global network to involve diaspora and international investors in Armenian deals.

Triple S has also co-launched the Los Angeles chapter of the Science & Technology Angels Network (STAN LA). Where does this platform fit into your strategy?

Avag Simonyan: Diaspora Armenian founders often have world-class ideas but a thin community network in Silicon Valley. STAN LA aggregates more than 70 percent of its angels from California, 20 percent from Armenia, and 10 percent from Europe, then pairs that capital with mentorship circles. Deals aren’t transactional; they germinate in a community where trust is the default currency.

And what are Triple S Ventures’ upcoming goals?

Avag Simonyan: Firstly, we aim to keep identifying and supporting Armenian founders and startups that fit our vision of technological progress and positive social impact. Secondly, we will continue to expand our investment portfolio and strategic  engagement with the US startup ecosystem by investing in the US-based non-Armenian companies to create a better synergy between these two ecosystems. Fostering innovation across multiple sectors remains top priorities. We believe in the transformative power of innovation and are dedicated to helping entrepreneurs bring their groundbreaking ideas to life.

How has the experience of managing the fund altered your view of venture capital and entrepreneurship?

Avag Simonyan: Leading Triple S Ventures has been both eye-opening and transformative. It has reinforced my belief that investors must contribute not only capital but also time, expertise, and effort to founders who truly aim to drive change—especially in fields that profoundly affect societal well-being. It also underlines that entrepreneurship demands flexibility and continuous growth: understanding a founder’s daily challenges and tackling problems shoulder to shoulder.

Any final advice for founders seeking smart money and mentorship?

Avag Simonyan: Keep the clarity of your vision but stay flexible on execution. Choose investors who bring more than money—people who will challenge you, open doors, and celebrate the hard-won victories. And remember: the entrepreneurial journey is a marathon of personal growth as much as it is a business pursuit.